Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Production of endogenous pyrogen

C A Dinarello

    Federation Proceedings
    |January 1, 1979
    PubMed
    Summary

    Fever begins when the body produces endogenous pyrogen, a protein released by immune cells. This molecule acts on the brain to cause fever, with aggregates potentially enhancing its activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical, hematologic, and immunologic effects of interleukin-10 in humans.

    Journal of clinical immunology·1996
    Same author

    Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha.

    Arthritis and rheumatism·1996
    Same author

    Effect of endotoxin in IL-1 beta-deficient mice.

    Journal of immunology (Baltimore, Md. : 1950)·1996
    Same author

    Modulation of osteoclast-activating factor activity of multiple myeloma bone marrow cells by different interleukin-1 inhibitors.

    Experimental hematology·1996
    Same author

    Thermoregulation and the pathogenesis of fever.

    Infectious disease clinics of North America·1996
    Same author

    Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation.

    Cytokine·1996

    Area of Science:

    • Immunology
    • Molecular Biology
    • Physiology

    Background:

    • Fever pathogenesis involves endogenous pyrogen production.
    • Endogenous pyrogen is a low-molecular-weight protein from phagocytic leukocytes.
    • Diverse stimuli, including toxins, antigens, and macrophage tumors, trigger its release.

    Purpose of the Study:

    • To elucidate the role of endogenous pyrogen in fever development.
    • To describe the synthesis and release mechanisms of endogenous pyrogen.
    • To investigate the biological activity of endogenous pyrogen and its aggregates.

    Main Methods:

    • Analysis of endogenous pyrogen synthesis via DNA transcription and mRNA translation.
    • Observation of protein release mechanisms from leukocytes.
    • Investigation of molecular aggregation post-release.
    • Assessment of monomeric and aggregated forms' pyrogenic activity.

    Main Results:

    • Endogenous pyrogen is synthesized via new DNA transcription and mRNA translation.
    • The protein is released without significant intracellular storage.
    • Molecular aggregates of endogenous pyrogen are formed after release and are biologically active.
    • Monomeric endogenous pyrogen potently induces fever by acting on the thermoregulatory center.

    Conclusions:

    • Endogenous pyrogen is a key mediator in fever pathogenesis.
    • Its synthesis and release are tightly regulated processes.
    • Post-release aggregation influences biological activity, contributing to fever mediation.

    Related Experiment Videos