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Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4
Y Hashimoto1, H Kagechika, E Kawachi
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Journal of Cancer Research and Clinical Oncology
|January 1, 1995
Abstract:
Retinoids, including all-trans-retinoic acid, its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. A good linear correlation, with an r value of 0.91, between the ED50 values for the differentiation-inducing activity towards HL-60 cells and that towards NB4 cells was found.