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Related Experiment Videos

Calculation and number processing in mild Alzheimer's disease

G Deloche1, D Hannequin, S Carlomagno

  • 1Inserm, Hôpital de la Salpêtrière, Paris, France.

Journal of Clinical and Experimental Neuropsychology
|August 1, 1995
PubMed
Summary

Mild dementia of Alzheimer's type (DAT) impairs calculation and number processing, but abilities vary significantly between patients. Cognitive deficits in calculation, memory, and language show heterogeneous patterns in individuals with DAT.

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Area of Science:

  • Neuropsychology
  • Cognitive Neurology
  • Geriatric Medicine

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Mild dementia of Alzheimer's type (DAT) presents with cognitive deficits.
  • Calculation and number processing are complex cognitive functions potentially affected in DAT.

Purpose of the Study:

  • To assess calculation and number processing abilities in patients with mild DAT.
  • To investigate the relationship between calculation/number processing and other cognitive functions like memory and language.
  • To identify patterns of cognitive impairment in mild DAT using a standardized assessment.

Main Methods:

  • Utilized the EC301 standardized multitask assessment battery for 17 patients with mild DAT.

Related Experiment Videos

  • Employed a specific visuo-perceptive task for patient selection to control for digit serial order analysis deficits.
  • Evaluated language and memory skills using standardized testing procedures.

    • Main Results:

    • The EC301 overall score indicated impaired performance in 12 out of 17 patients.
    • Calculation and number processing scores correlated significantly with Mini-Mental State Examination and language performance.
    • Single-case analyses revealed heterogeneous patterns of preserved and impaired abilities across calculation, memory, and language domains.

    Conclusions:

    • Mild DAT affects calculation and number processing abilities.
    • Cognitive deficits in mild DAT are heterogeneous, impacting different cognitive domains and their subcomponents.
    • Further research is needed to understand the specific neural mechanisms underlying these heterogeneous deficits in DAT.