Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of risperidone on hostility in schizophrenia

P Czobor1, J Volavka, R C Meibach

  • 1Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

Journal of Clinical Psychopharmacology
|August 1, 1995
PubMed
Summary

Risperidone showed a greater selective effect on reducing hostility in schizophrenia patients compared to haloperidol and placebo. This suggests potential for risperidone in managing aggressive behaviors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative effectiveness of second generation long-acting injectable antipsychotics based on nationwide database research in Hungary.

PloS one·2019
Same author

Mortality and the relationship of somatic comorbidities to mortality in schizophrenia. A nationwide matched-cohort study.

European psychiatry : the journal of the Association of European Psychiatrists·2017
Same author

Hostility in schizophrenia: An integrated analysis of the combined Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and the European First Episode Schizophrenia Trial (EUFEST) studies.

European psychiatry : the journal of the Association of European Psychiatrists·2015
Same author

Is ADHD severity in adults associated with the lifetime prevalence of comorbid depressive episodes and anxiety disorders?

European psychiatry : the journal of the Association of European Psychiatrists·2012
Same author

P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis.

Psychological medicine·2010
Same author

Executive function in deficit schizophrenia: what do the dimensions of the Wisconsin Card Sorting Test tell us?

Schizophrenia research·2010

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Hostility is a significant symptom in schizophrenia.
  • Understanding medication effects on hostility is crucial for patient management.

Purpose of the Study:

  • To investigate the selective effects of risperidone on hostility in schizophrenia.
  • To compare risperidone's efficacy against haloperidol and placebo.

Main Methods:

  • A 9-week, multicenter, placebo-controlled, double-blind clinical trial.
  • 139 patients diagnosed with DSM-III-R schizophrenia were included.
  • Hostility was measured using the Positive and Negative Syndrome Scale, with psychosis changes as a covariate.

Main Results:

  • Risperidone demonstrated a significantly greater selective effect on reducing hostility than haloperidol or placebo.

Related Experiment Videos

  • This effect was independent of changes in overall psychosis symptoms.

    • Conclusions:

    • Risperidone exhibits a selective beneficial effect on hostility in schizophrenia.
    • Findings support exploring risperidone for patients with significant physical aggression.