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Related Experiment Videos

Immunosuppressive therapy prevents recurrent pericarditis

R Marcolongo1, R Russo, F Laveder

  • 1Department of Clinical Medicine, Padua University School of Medicine, Italy.

Journal of the American College of Cardiology
|November 1, 1995
PubMed
Summary

High-dose prednisone with aspirin effectively treats recurrent pericarditis, achieving remission in most patients. Steroid-sparing agents like azathioprine or cyclophosphamide are options for refractory cases or those with severe side effects.

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Area of Science:

  • Cardiology
  • Immunology

Background:

  • Recurrent pericarditis often persists despite anti-inflammatory drugs.
  • The efficacy and safety of steroid use in recurrent pericarditis are debated.

Purpose of the Study:

  • To evaluate the clinical outcomes of recurrent pericarditis patients treated with immunosuppressive therapy.
  • To assess the effectiveness of high-dose prednisone and adjunctive therapies.

Main Methods:

  • Twelve patients with recurrent pericarditis received a 3-month course of high-dose prednisone (1-1.5 mg/kg/day) followed by gradual withdrawal.
  • Aspirin was administered concurrently, with dosage adjustments.
  • Azathioprine or cyclophosphamide were used in specific cases due to adverse effects or lack of response.

Main Results:

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  • High-dose prednisone achieved stable remission in 11 out of 12 patients.
  • One patient required azathioprine for persistent remission after initial prednisone treatment.
  • Three patients experienced severe steroid-related adverse effects, necessitating alternative immunosuppressive agents without compromising outcomes.

Conclusions:

  • Prednisone dosage and duration are crucial for managing recurrent pericarditis.
  • High-dose prednisone combined with aspirin is a recommended treatment for steroid-resistant recurrent pericarditis.
  • Steroid-sparing agents are valuable for patients with refractory disease or significant steroid toxicity.