Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hyperparathyroidism in multiple endocrine neoplasia type 2A

F Raue1, J L Kraimps, H Dralle

  • 1Medizinische Universitätsklinik, Heidelberg, Germany.

Journal of Internal Medicine
|October 1, 1995
PubMed
Summary

Primary hyperparathyroidism in multiple endocrine neoplasia type 2A (MEN 2A) is often asymptomatic and mild. Surgical resection of enlarged parathyroid glands typically cures this condition, even in rare MEN 2A cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up": [Annals of Oncology 32 (2021) 439-451].

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

A multigenomic liquid biopsy biomarker for neuroendocrine tumor disease outperforms CgA and has surgical and clinical utility.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Management of primary and renal hyperparathyroidism: guidelines from the German Association of Endocrine Surgeons (CAEK).

Langenbeck's archives of surgery·2021
Same author

Omission of lateral lymph node dissection in medullary thyroid cancer without a desmoplastic stromal reaction.

The British journal of surgery·2021
Same author

Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up<sup>☆</sup>.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

[EUROCRINE®: adrenal surgery 2015-2019- surprising initial results].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2020

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Genetics

Background:

  • Primary hyperparathyroidism (PHPT) is rare in multiple endocrine neoplasia type 2A (MEN 2A).
  • Understanding PHPT in MEN 2A is crucial for effective management strategies.

Purpose of the Study:

  • To evaluate the clinical findings, surgical therapy, and outcomes of PHPT in patients with MEN 2A.
  • To assess the efficacy of therapeutic strategies for PHPT in this rare genetic disorder.

Main Methods:

  • Retrospective study of 67 patients with MEN 2A and PHPT, registered by the EUROMEN study group (1972-1993).
  • Review of clinical characteristics, surgical interventions (adenomectomy, subtotal/total parathyroidectomy), and follow-up data.
  • Histological and biochemical confirmation of PHPT.

Related Experiment Videos

Main Results:

  • PHPT was diagnosed synchronously with medullary thyroid carcinoma in 75% of patients.
  • 84% of PHPT cases were asymptomatic; 15% presented with renal stones.
  • Surgical cure was achieved in 94% of patients, with recurrence in 12% over 8 years.

Conclusions:

  • MEN 2A-related PHPT typically presents with mild, asymptomatic hypercalcemia.
  • Simple resection of enlarged parathyroid glands is effective in most cases.
  • Surgical management offers a high cure rate for PHPT in MEN 2A patients.