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Related Experiment Videos

Visualizing the marrow granulocyte reserve

R A Joyce, D R Boggs

    The Journal of Laboratory and Clinical Medicine
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    The marrow granulocyte reserve (MGR) was assessed in neutropenic patients. Marrow differential counts, specifically the percentage of band and segmented neutrophils, effectively predict endotoxin response, simplifying MGR assessment.

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    Experimental hematology·1989

    Area of Science:

    • Hematology
    • Immunology
    • Cell Biology

    Background:

    • The marrow granulocyte reserve (MGR) is crucial for meeting sudden demands for blood neutrophils.
    • Assessing MGR traditionally involves measuring blood neutrophil increments after stimuli or estimating marrow size.
    • Neutropenia, a condition of low neutrophil count, necessitates understanding MGR function.

    Purpose of the Study:

    • To evaluate the MGR in patients with neutropenia.
    • To compare MGR assessment methods: endotoxin response vs. marrow differential counts.
    • To identify predictors of endotoxin response in neutropenic individuals.

    Main Methods:

    • Conducted 34 studies on 31 patients with diverse causes of neutropenia.
    • Measured MGR by comparing endotoxin response with marrow differential counts and estimated marrow mass.

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  • Analyzed the correlation between marrow neutrophil precursor percentages and endotoxin response.

    • Main Results:

    • Endotoxin responses were normal in 10 studies and subnormal in 24.
    • The percentage of band and segmented neutrophils and their precursors in the marrow best predicted endotoxin response.
    • Marrow neutrophils and precursors >25% (band and segmented) correlated with normal endotoxin response; <25% correlated with subnormal response.

    Conclusions:

    • Marrow differential counts, specifically the percentage of band and segmented neutrophils, are reliable indicators of MGR.
    • Measuring endotoxin response provides no additional information when marrow aspirates show a reduced percentage of band and segmented neutrophils.
    • Simplified MGR assessment is possible using marrow differential counts in neutropenic patients.