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Related Experiment Videos

Distribution of ethanol in postmortem liver

A J Jenkins1, B S Levine, J E Smialek

  • 1Office of the Chief Medical Examiner, State of Maryland, Baltimore, USA.

Journal of Forensic Sciences
|July 1, 1995
PubMed
Summary

Liver tissue can be a viable alternative for ethanol analysis in postmortem toxicology when blood samples are unavailable. This study found a consistent liver-to-blood ethanol ratio, aiding interpretation.

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Area of Science:

  • Forensic Toxicology
  • Postmortem Analysis
  • Analytical Chemistry

Background:

  • Ethanol analysis in postmortem toxicology is crucial.
  • Blood is the standard specimen, but alternatives are needed when unavailable or contaminated.
  • Limited data exists on ethanol distribution in liver tissue postmortem.

Purpose of the Study:

  • To investigate the distribution of ethanol in liver tissue compared to heart blood.
  • To determine the reliability of liver tissue for ethanol analysis in postmortem cases.

Main Methods:

  • Analysis of heart blood and liver specimens for ethanol.
  • Utilized headspace gas chromatography.
  • Included 103 postmortem cases.

Main Results:

  • Calculated the average liver/heart blood ethanol ratio in cases with a blood alcohol concentration (BAC) >= 0.04 g/dL.
  • The average ratio was 0.56 (SD = 0.30), ranging from 0 to 1.40.

Conclusions:

  • Liver tissue can be a valuable specimen for ethanol determination in postmortem toxicology.
  • The established liver/heart blood ratio aids in interpreting ethanol levels when blood is compromised.

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