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Novel chlorinated tropanes derived from the treatment of cocaine with sodium hypochlorite
J F Casale1, J M Moore, D A Cooper
1Special Testing and Research Laboratory, U.S. DEA, McLean, VA, USA.
Journal of Forensic Sciences
|September 1, 1995
Abstract:
Several novel chlorinated tropanes were produced when cocaine was treated with aqueous sodium hypochlorite. Two of these, 2'- and 3'-chlorobenzoyloxy-2-carbomethoxypseudotropine (that is, ortho- and meta-chlorococaine), were characterized by synthesis and gas chromatography/mass spectrometry. Four other new chlorinated tropanes (endo-6- and 7-chlorococaine, exo-6- or 7-chlorococaine and N-chlorobenzoylnorecgonine methyl ester) were also tentatively identified via their gas chromatography retention data and mass spectra. The results are of potential use in cocaine signature and comparative analysis.