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The future of microbial insecticides as vector control agents
1Department of Entomology, University of California, Riverside 92521, USA.
Abstract:
Insect vectors of human diseases are subject to diseases of their own caused by viruses, bacteria, fungi, protozoans, and nematodes. Over the past 30 years, many members of these groups have been evaluated as vector control agents, particularly for mosquito control. Most pathogens and nematodes occur primarily in larvae, and are only effective against this stage. The principal candidate control agents studied include iridescent and nuclear polyhedrosis viruses, the bacteria Bacillus thuringiensis and Bacillus sphaericus, the fungi Lagenidium giganteum, Culicinomyces clavosporus, and species of the genus Coelomomyces, the protozoan Nosema algerae, and the mermithid nematode Romanomermis culicivorax. Of these, the only one considered an operational success is the bacterium, Bacillus thuringiensis subsp. israelensis (B.t.i.), which has proven useful for control of both mosquito and blackfly larvae in programs where larviciding has been traditionally employed as a vector control tactic. The reasons for the success of B.t.i. are its cost-effectiveness and relative ease of use, which are due, respectively, to the ability of B.t.i. to be grown on artificial media and the development of formulations that can be applied using conventional insecticide application technology. Because few microbial insecticides are cost-effective, and those that are are only effective against larvae, these agents will likely play only a minor, but in some cases important, role in most future vector control programs.
Insights
Bacillus thuringiensis subsp. israelensis (B.t.i.) is the only microbial insecticide proven effective for controlling mosquito and blackfly larvae. Its success stems from cost-effectiveness and ease of application in vector control programs.
Area of Science:
- Entomology
- Microbial Control
- Public Health
Background:
- Insect vectors transmit human diseases and are susceptible to various pathogens.
- Microbial agents, including viruses, bacteria, fungi, protozoans, and nematodes, have been explored for vector control over 30 years.
- Most microbial agents are effective only against larval stages of insect vectors.
Purpose of the Study:
- To review the efficacy of various microbial agents as vector control agents.
- To identify factors contributing to the operational success of microbial insecticides.
- To assess the potential role of microbial agents in future vector control strategies.
Main Methods:
- Literature review of microbial pathogens and nematodes evaluated for vector control.
- Analysis of the effectiveness and limitations of different microbial agents (viruses, bacteria, fungi, protozoans, nematodes).
- Evaluation of Bacillus thuringiensis subsp. israelensis (B.t.i.) as a case study for successful microbial control.
Main Results:
- Bacillus thuringiensis subsp. israelensis (B.t.i.) is the only microbial insecticide to achieve operational success in vector control.
- B.t.i. is effective against mosquito and blackfly larvae, particularly in programs using traditional larviciding.
- Cost-effectiveness and ease of application, due to artificial media cultivation and advanced formulations, are key to B.t.i.'s success.
Conclusions:
- Microbial insecticides, while effective against larvae, face challenges in cost-effectiveness for widespread vector control.
- B.t.i. represents a significant advancement in microbial vector control due to its practical advantages.
- Microbial agents are expected to play a supplementary but important role in integrated vector management programs.
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