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Proliferative potential of meningiomas evaluated by proliferating cell nuclear antigen expression
H Nakabayashi1, M Sakaguchi, J Katsuyama
1Department of Neurosurgery, Shimada Municipal Hospital, Shizuoka, Japan.
Journal of Neuro-Oncology
|January 1, 1995
Summary
The proliferating cell nuclear antigen (PCNA) index can predict meningioma behavior. Higher PCNA index values indicate faster tumor growth and recurrence risk in meningioma patients.
Area of Science:
- Neuro-oncology
- Pathology
- Molecular Biology
Background:
- Meningiomas are typically benign tumors.
- Predicting meningioma biological behavior is challenging with conventional histopathology.
- Some meningiomas exhibit aggressive growth or recurrence post-surgery.
Purpose of the Study:
- To evaluate the utility of the proliferating cell nuclear antigen (PCNA) index for assessing meningioma proliferative activity.
- To correlate PCNA index with clinical outcomes like recurrence and tumor doubling time.
Main Methods:
- Examined 52 meningiomas using a monoclonal antibody against PCNA.
- Calculated the PCNA index for each tumor.
- Performed statistical analyses including regression to correlate PCNA index with tumor behavior and other markers.
Main Results:
- Recurrent meningiomas showed a significantly higher mean PCNA index (3.37%) compared to non-recurrent ones (1.12%).
- PCNA indices in recurrent cases exceeded 2.0%.
- Significant correlations were found between PCNA index and tumor doubling time (r=0.90), interval to recurrence (r=0.62), and BUdR labeling index (r=0.88).
Conclusions:
- The PCNA index is a valuable tool for estimating meningioma biological behavior.
- Standardized methods for tissue processing and analysis are crucial for reliable PCNA index assessment.
- PCNA index can aid in predicting recurrence risk and tumor aggressiveness.