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Related Experiment Videos

Malignant solid tumors in neonates: a 40-year review

H Xue1, J R Horwitz, M B Smith

  • 1Division of Pediatric Surgery, University of Texas Medical School, Houston, USA.

Journal of Pediatric Surgery
|April 1, 1995
PubMed
Summary

Neonatal solid tumors have a good prognosis in infants without distant metastatic disease. Early detection and treatment are crucial for improving survival rates in these rare pediatric cancers.

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Area of Science:

  • Pediatric Oncology
  • Neonatal Medicine
  • Cancer Research

Background:

  • Neonatal malignant solid tumors are rare but aggressive pediatric cancers.
  • Understanding outcomes is vital for improving treatment strategies.

Purpose of the Study:

  • To evaluate the outcomes of neonatal malignant solid tumors.
  • To identify prognostic factors for survival in affected infants.

Main Methods:

  • Retrospective review of 222 infants (<1 year) with malignancies.
  • Focus on 32 infants with neonatal solid tumors (<30 days old).
  • Analysis of tumor types, sites, treatments, and survival rates.

Main Results:

  • Common diagnoses included soft tissue sarcoma, neuroblastoma, and brain tumors.

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  • Most tumors presented at or within the first week of life.
  • Overall survival was 78%, with no survivors among those with distant metastatic disease at diagnosis.

    • Conclusions:

    • Prognosis for neonatal solid tumors is excellent in the absence of distant metastatic disease.
    • Extracranial tumors, in particular, show a favorable outlook.
    • Early diagnosis and intervention are critical for improving survival in neonatal malignancies.