The rationale for using logarithmic transformation of concentration data in toxicokinetic studies
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Updated: Oct 2, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
1Department of R&D Information Management, Eisai Co., Ltd., Tokyo, Japan.
Abstract:
The present paper focuses on the necessity of logarithmic transformation of plasma concentration in toxicokinetic studies. The dose-plasma concentration relationship is the most important subject to be studied, because test doses rise over a wide range from therapeutic dose level to toxic dose level in toxicity studies. It is concluded that the logarithmic transformation of concentration data effectively stabilized the variances, and the regression analysis of log-transformed data makes it possible to quantitatively evaluate the magnitude of non-linear kinetics of test compounds in toxicity studies.
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