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Specific immune tolerance related to disparity in MHC class I region
1University Hospital Blood Center, Lund, Sweden.
A specific immune tolerance in mature, immunologically competent individuals may be induced by incompatibility for some of the class I major histocompatibility complex (MHC) antigens. This is suggested by results of experimental and clinical studies of organ transplantation and of antibody production. These results indicate the existence of tolerance-promoting allogenic markers within the MHC class I region.
A specific immune tolerance in mature, immunologically competent individuals may be induced by incompatibility for some of the class I major histocompatibility complex (MHC) antigens. This is suggested by results of experimental and clinical studies of organ transplantation and of antibody production. These results indicate the existence of tolerance-promoting allogenic markers within the MHC class I region.