Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphostasis and immunity

J Cunliffe1

  • 1Waterside Health Centre, Hythe, Southampton, UK.

Medical Hypotheses
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

This study proposes a new paradigm for self/non-self discrimination, suggesting it originates from embryonic cell sorting mechanisms, not solely lymphocytes. Lymphocytes are re-envisioned to classify cell death modes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measles surveillance in Canada: 2015.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2018
Same author

Guidelines on radiographic imaging as part of root canal treatment: a systematic review with a focus on review imaging after treatment.

International endodontic journal·2017
Same author

Subperiosteal implants.

British dental journal·2012
Same author

A proliferation of pathogens through the 20th century.

Scandinavian journal of immunology·2008
Same author

Intentional pathogen killing--or denial of substrate?

Scandinavian journal of immunology·2007
Same author

Tissue homeostasis and immunity--more on models.

Scandinavian journal of immunology·2006
Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026
Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025
Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025
Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025
Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024
Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
See all related articles

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Traditional immunology posits lymphocytes are central to self/non-self discrimination.
  • This view has remained largely unchallenged despite potential limitations.

Purpose of the Study:

  • To propose a novel hypothesis for self/non-self discrimination.
  • To challenge the established paradigm of immune recognition.
  • To provide a new framework for understanding tissue homeostasis and immune system evolution.

Main Methods:

  • Conceptual hypothesis development.
  • Comparative analysis of immune mechanisms and embryonic cell sorting.
  • Integration of morphostasis principles.

Main Results:

Related Experiment Videos

  • Self/non-self discrimination is proposed to be driven by mechanisms akin to embryonic cell sorting.
  • Lymphocytes' role is redefined to classifying cell death (apoptosis vs. necrosis).
  • The hypothesis offers a detailed account of mammalian immune system evolution and morphostasis.

Conclusions:

  • The established view of lymphocyte-mediated self/non-self discrimination requires a paradigm shift.
  • Embryonic cell sorting mechanisms offer a more fundamental explanation for immune recognition.
  • This new perspective potentially unifies developmental and immunological processes.