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Thyroplasty using a silicone elastomer implant

P D Righi1, K M Wilson, J L Gluckman

  • 1University of Cincinnati Medical Center, Ohio, USA.

Otolaryngologic Clinics of North America
|April 1, 1995
PubMed
Summary
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Silicone implants are not biologically inert but silicone elastomer is safe for laryngeal use, showing no links to immune disease or cancer. Further research into host-implant interactions is recommended.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Otolaryngology

Background:

  • Silicone has been utilized as a soft tissue replacement for over 30 years.
  • Recent research questions the biological inertness of silicone, exploring its local, systemic, and immune effects.

Purpose of the Study:

  • To evaluate the safety and biological interactions of silicone elastomer implants in the larynx.
  • To determine if silicone elastomer is associated with systemic immune diseases or cancer.

Main Methods:

  • Review of current scientific literature on silicone biocompatibility and host interactions.
  • Analysis of data regarding local, systemic, and immunological responses to silicone implants.

Main Results:

Related Experiment Videos

  • Silicone is not biologically inert, with known local, systemic, and immune effects.
  • Silicone elastomer has not been linked to systemic immune disease or carcinogenesis.
  • Evidence supports the ongoing use of silicone elastomer implants in laryngeal applications.

    • Conclusions:

    • Silicone elastomer implants are considered safe for laryngeal reconstruction.
    • Continued investigation into the biological properties and host-silicone interactions is necessary.