Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Life-threatening Pyridium Plus intoxication: a case report

T L Truman1, J J Dallessio, R E Weibley

  • 1University of South Florida College of Medicine, Department of Pediatrics, Davis Island, USA.

Pediatric Emergency Care
|April 1, 1995
PubMed
Summary

A child overdosed on Pyridium Plus, experiencing seizures and coma. Treatment involved methylene blue for methemoglobinemia, with pulse oximetry considerations during treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reduction of bleomycin-induced acute DNA injury in the rat lung by the 21-aminosteroid, U-74389G.

Critical care medicine·1997
Same author

Management of a traumatic pulmonary pseudocyst using high-frequency oscillatory ventilation.

The Journal of trauma·1995
Same author

The MORE HEALTH bicycle safety project.

The Journal of school health·1995
Same author

Autopsies and the pediatric intensive care unit.

Pediatric clinics of North America·1994
Same author

Life-threatening Pyridium Plus intoxication: a case report.

Pediatric emergency care·1994
Same author

Sertraline intoxication in a child.

Annals of emergency medicine·1994

Area of Science:

  • Toxicology
  • Pediatric Emergency Medicine
  • Pharmacology

Background:

  • Pyridium Plus overdose in pediatric patients is rare but can cause severe toxicity.
  • The combination of anticholinergic, azo dye, and barbiturate in Pyridium Plus presents a complex toxicological challenge.

Observation:

  • A 16-month-old male ingested Pyridium Plus, leading to seizures, coma, and methemoglobinemia.
  • Methemoglobinemia, a condition reducing oxygen-carrying capacity of blood, was a critical complication.

Findings:

  • Treatment strategies included methylene blue, activated charcoal, and exchange transfusion for methemoglobinemia.
  • The study highlights the challenges in monitoring oxygen saturation using pulse oximetry in patients with methemoglobinemia, especially during methylene blue treatment.

Related Experiment Videos

Implications:

  • This case underscores the importance of prompt recognition and management of Pyridium Plus toxicity in children.
  • Understanding the limitations of pulse oximetry in methemoglobinemia is crucial for accurate patient assessment and effective treatment.
  • Methylene blue remains a key antidote for methemoglobinemia, but careful monitoring is essential.