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Life-threatening Pyridium Plus intoxication: a case report

T L Truman1, J J Dallessio, R E Weibley

  • 1University of South Florida College of Medicine, Department of Pediatrics, Davis Island, USA.

Pediatric Emergency Care
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

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A child overdosed on Pyridium Plus, experiencing seizures and coma. Treatment involved methylene blue for methemoglobinemia, with pulse oximetry considerations during treatment.

Area of Science:

  • Toxicology
  • Pediatric Emergency Medicine
  • Pharmacology

Background:

  • Pyridium Plus overdose in pediatric patients is rare but can cause severe toxicity.
  • The combination of anticholinergic, azo dye, and barbiturate in Pyridium Plus presents a complex toxicological challenge.

Observation:

  • A 16-month-old male ingested Pyridium Plus, leading to seizures, coma, and methemoglobinemia.
  • Methemoglobinemia, a condition reducing oxygen-carrying capacity of blood, was a critical complication.

Findings:

  • Treatment strategies included methylene blue, activated charcoal, and exchange transfusion for methemoglobinemia.
  • The study highlights the challenges in monitoring oxygen saturation using pulse oximetry in patients with methemoglobinemia, especially during methylene blue treatment.

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Implications:

  • This case underscores the importance of prompt recognition and management of Pyridium Plus toxicity in children.
  • Understanding the limitations of pulse oximetry in methemoglobinemia is crucial for accurate patient assessment and effective treatment.
  • Methylene blue remains a key antidote for methemoglobinemia, but careful monitoring is essential.