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Childhood neurological disorders in twins
1Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Paediatric and Perinatal Epidemiology
|April 1, 1995
Summary
Neurological outcomes in twins show higher rates of death and cerebral palsy. However, low birthweight and co-twin survival status are key predictors of neurological issues in childhood.
Area of Science:
- Neurology
- Pediatrics
- Genetics
Background:
- Twin studies are crucial for understanding developmental outcomes.
- Neurological morbidity in twins requires further investigation.
Purpose of the Study:
- To examine neurological outcomes in twins up to age 7.
- To identify predictors of neurological morbidity in twin infants.
Main Methods:
- Multi-center prospective cohort study.
- Follow-up of 1079 twins from livebirth to 7 years.
- Outcome measures included death, cerebral palsy, seizure disorders, and intelligence quotient.
Main Results:
- Twins had higher rates of fetal/neonatal death and cerebral palsy than singletons.
- Low birthweight twins (<2500g) did not have higher cerebral palsy risk than low birthweight singletons.
- Death of a co-twin increased cerebral palsy and nonfebrile seizure risk in survivors.
Conclusions:
- Low birthweight and co-twin survival status are dominant predictors of neurological morbidity in twins.
- Specific neurological outcomes vary based on birthweight and co-twin status.