Related Experiment Video
Updated: Aug 12, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Aspirin and colorectal cancer: the Leisure World cohort revisited
1Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90031, USA.
Abstract:
The Leisure World Cohort data on aspirin and colorectal cancer was reanalyzed in an attempt to explain why this study is the lone observational study in which aspirin appears not to be protective. Aspirin users differed from nonusers on a number of baseline variables, some of which are related to risk of colorectal cancer. After adjustment for these variables, aspirin use still did not appear to be protective. The Leisure World cohort members are considerably older than subjects in the other studies; analyses limited to subjects younger than 75 years showed a slightly protective effect of aspirin in men but not in women. A resurvey 5 years after the start of the study indicated that one-third of the subjects had changed the frequency of their aspirin intake. About 25% of daily analgesic users reported their primary reason for using aspirin to be for preventing heart disease and stroke. Regular aspirin use at a dose adequate for preventing cardiovascular disease may be insufficient for preventing colorectal cancer.
More Related Videos
06:24Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
Published on: October 13, 2023
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Related Concept Videos
Cancer Prevention
Some...
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease II: Ulcerative Colitis
Diverticular Disease of the Colon