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[Non-infectious inflammatory fasciitis: a borderline syndrome]
1Service de médicine interne, hôpital Claude-Huriez, Lille, France.
La Revue De Medecine Interne
|January 1, 1995
Summary
Non-infectious inflammatory fasciitis encompasses various conditions presenting with scleroderma-like skin changes. Diagnosis can be challenging, with eosinophilia being a key, though not always present, indicator.
Area of Science:
- Dermatology
- Rheumatology
- Pathology
Context:
- Inflammatory fasciitis without infection comprises diverse conditions, including eosinophilic fasciitis and toxic oil syndrome.
- These conditions can present with scleroderma-like skin manifestations, complicating diagnosis.
- Distinguishing these entities from scleroderma is challenging due to overlapping clinical and histopathological features.
Purpose:
- To delineate the spectrum of non-infectious inflammatory fasciitis.
- To highlight diagnostic challenges and key differentiating features.
- To emphasize the role of eosinophils in the pathogenesis of these conditions.
Summary:
- Non-infectious inflammatory fasciitis includes entities like eosinophilic fasciitis, eosinophilia-myalgia syndrome, toxic oil syndrome, and others.
- Diagnosis is often difficult due to borderline presentations resembling scleroderma.
- Eosinophilia and fascial eosinophilic infiltration are characteristic but can be absent or transient; patient history is crucial.
Impact:
- Improved diagnostic accuracy for non-infectious fasciitis.
- Enhanced understanding of the pathogenesis involving eosinophils.
- Better patient management through accurate differentiation from scleroderma.