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[Hodgkin disease: recent histological and biological data]
1Service d'anatomie et de cytologie pathologiques, CHU Pitié-Salpêtrière, Paris, France.
La Revue De Medecine Interne
|January 1, 1995
Summary
Recent research reclassifies Hodgkin's disease (HD), suggesting the Rye classification needs revision. New findings indicate Reed-Sternberg cells in HD may originate from various lymphocytes and are linked to Epstein-Barr virus.
Area of Science:
- Hematology
- Oncology
- Immunology
Context:
- The Rye classification of Hodgkin's disease (HD) is outdated.
- Histologic, immunophenotypic, and genotypic data necessitate a re-evaluation of HD classification.
- Previous classifications have miscategorized certain B-cell lymphomas and T-cell-rich large B-cell non-Hodgkin's lymphomas (NHL).
Purpose:
- To revise the current classification of Hodgkin's disease based on recent scientific data.
- To clarify the origins and characteristics of Reed-Sternberg and Hodgkin's (RSH) cells.
- To explore the role of Epstein-Barr virus (EBV) and cytokines in the pathogenesis of HD.
Summary:
- Recent data suggest Hodgkin's disease (HD) should be restricted to types 2 and 3 of the Rye classification, requiring revision.
- The lymphocyte-predominance type includes B-cell lymphomas and cases confused with T-cell-rich large B-cell non-Hodgkin's lymphoma (NHL).
- Reed-Sternberg and Hodgkin's (RSH) cells are heterogeneous, potentially derived from B, T, or null lymphocytes, with 50% harboring Epstein-Barr virus (EBV) and producing cytokines.
Impact:
- This study prompts a revision of the Hodgkin's disease classification.
- It clarifies the heterogeneous nature of Reed-Sternberg cells and their potential origins.
- It highlights the oncogenic role of Epstein-Barr virus and the significance of cytokine production in HD pathogenesis.