Diarrhea-associated hemolytic-uremic syndrome in a child with nail-patella syndrome

A 5-year-old girl with nail-patella syndrome had diarrhea-associated hemolytic-uremic syndrome. Nail-patella syndrome is associated with a glomerulopathy characterized by the presence of fibrillar collagen within the glomerular basement membrane. Hemolytic-uremic syndrome has also been reported in patients with collagen type III glomerulopathy, a disorder also characterized by the presence of fibrillar collagen within the basement membrane. Patients with nail-patella syndrome or with collagen type III glomerulopathy may be predisposed to hemolytic-uremic syndrome.