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Related Experiment Videos

Tomographic time-of-flight optical imaging device

D A Benaron1, D C Ho, S Spilman

  • 1Medical Imaging and Spectroscopy Section, Stanford School of Medicine, Palo Alto, CA, USA.

Advances in Experimental Medicine and Biology
|January 1, 1994
PubMed
Summary
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Time-resolved optical tomography enables functional brain imaging. This new rotational scanner can produce recognizable images of brain pathology, paving the way for clinical use.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Optical Tomography

Background:

  • Time-resolved optical imaging shows promise for functional human tissue imaging, including brain oxygenation during stroke.
  • Previous work focused on transmission scanners; this study reports conversion to a rotational tomographic scanner.

Purpose of the Study:

  • To report on the conversion of a transmission optical scanner to a rotational tomographic scanner.
  • To assess the feasibility of optical tomography for clinical applications, particularly brain imaging.

Main Methods:

  • Utilized time-of-flight measurements and non-recursive algorithms with a rotational tomographic scanner.
  • Employed a non-parallel ray geometry similar to early computed tomography (CAT) scanners.
  • Tested imaging capabilities in phantoms and animal models, including simulated brain pathology.

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Main Results:

  • Demonstrated spatial imaging in turbid media is possible.
  • Achieved separation of absorbance and scattering for chemometric analysis.
  • Showed feasibility of imaging multiple objects in scattering media, applicable to inhomogeneous media.
  • Produced recognizable images of brain pathology with diagnostic resolution.

Conclusions:

  • Optical tomography is feasible for clinical use.
  • The current device can be converted to a clinical scanner retaining processing algorithms.
  • A clinical scanner could generate images within minutes with centimeter resolution for living human brain imaging.