Related Experiment Videos
Pulmonary function after non-heart-beating lung donation in a survival model
S A Buchanan1, N F DeLima, O A Binns
1Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
The Annals of Thoracic Surgery
|July 1, 1995
Summary
Lung transplants from non-heart-beating donors (NHBD) show promising results. Lungs harvested up to 15 minutes after circulatory arrest function comparably to those from heart-beating donors, expanding donor pool options.
Area of Science:
- Transplantation immunology
- Thoracic surgery
- Organ donation
Background:
- Lung transplantation is limited by donor availability.
- Procurement from non-heart-beating donors (NHBD) could expand the donor pool.
- This study investigates the viability of NHBD lungs for transplantation.
Purpose of the Study:
- To evaluate the post-transplantation function of lungs procured from NHBD.
- To compare NHBD lung function with lungs from heart-beating donors.
- To determine the impact of warm ischemia time on NHBD lung viability.
Main Methods:
- Adult swine underwent left lung allotransplantation.
- Lungs were procured from heart-beating donors (controls) and NHBD.
- NHBD lungs were harvested immediately, or after 15 or 30 minutes of warm ischemia post-asphyxiation.
Main Results:
- After 1 week, airway compliance was similar between controls and NHBD (0 min ischemia).
- NHBD lungs with up to 15 minutes of warm ischemia showed comparable function to controls.
- A significant decrease in airway compliance was observed in the NHBD-30 group (30 min ischemia).
Conclusions:
- NHBD lung transplantation is feasible with up to 15 minutes of warm ischemia.
- Prolonged warm ischemia (30 minutes) may exacerbate reperfusion injury.
- NHBD lung procurement, within specific timeframes, is a viable strategy to increase donor lung availability.