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Related Experiment Videos

Oxygenator with built-in hemoconcentrator: a new concept

H Nishida1, M Endo, H Koyanagi

  • 1Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College.

Artificial Organs
|April 1, 1995
PubMed
Summary

This study introduces a novel membrane oxygenator combining gas exchange and hemoconcentration for cardiopulmonary bypass. The integrated device simplifies circuits and enhances efficiency in open-heart surgery without transfusions.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Medical Devices

Background:

  • Open-heart surgery often requires cardiopulmonary bypass, which can involve complex extracorporeal blood circuits.
  • Blood transfusion avoidance is a critical aspect of modern surgical procedures.
  • Existing devices for gas exchange and hemoconcentration are often separate components, complicating the surgical setup.

Purpose of the Study:

  • To develop a novel membrane oxygenator with integrated hemoconcentration functionality.
  • To simplify the extracorporeal blood circuit used in cardiopulmonary bypass.
  • To improve the handling and efficiency of blood management during open-heart surgery.

Main Methods:

  • A new cylindrical device was engineered, integrating hollow fibers for gas exchange and hemoconcentration.

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  • The device utilizes a blood outside perfusion system with a unique flow mode for even blood distribution.
  • The combined unit was tested for oxygen transfer and ultrafiltration rates under specific flow conditions.

    • Main Results:

    • The integrated device demonstrated an oxygen transfer rate of 317 ml/min at 6 L/min flow rate.
    • An ultrafiltration rate of 7 L/h was achieved at 4 L/min flow rate with a 25% hematocrit.
    • No adverse effects were observed from the combined structure of the oxygenator and hemoconcentrator.

    Conclusions:

    • The novel membrane oxygenator effectively combines oxygenation and hemoconcentration functions in a single component.
    • The adopted blood outside flow mode ensures even blood distribution, enhancing device performance.
    • This integrated device offers a simplified and efficient solution for hemoconcentration during cardiopulmonary bypass, crucial for transfusion-free open-heart surgery.