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C3.SW-Soaa heterozygous congenic taster mice

J D Boughter¹, G Whitney

¹Department of Psychology, Florida State University, Tallahassee 32306-1051, USA.

Behavior Genetics

|May 1, 1995

Summary

Mice taste sensitivity to bitter sucrose octaacetate (SOA) is controlled by a single gene. Researchers created new mouse models to study this gene

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Area of Science:

Genetics
Neuroscience
Animal Models

Background:

Taste perception varies among inbred mouse strains regarding the bitter compound sucrose octaacetate (SOA).
These strains exhibit distinct phenotypes: tasters, nontasters, and demitasters (intermediate sensitivity).
Previous research utilized a congenic quartet to explore the Soa locus's influence on non-SOA taste sensitivity.

Purpose of the Study:

To develop a new congenic mouse model (C3.SW-Soaa) for studying taste genetics.
To validate the monogenic inheritance of the Soa locus using taster and demitaster strains.
To provide a resource for further investigation into taste perception mechanisms.

Main Methods:

Creation of a congenic mouse set (C3.SW-Soaa) from SWR/J (taster) and C3HeB/FeJ (demitaster) strains.
Utilizing 11 lineal backcross generations to establish a 99% C3 demitaster genetic background.
Phenotypic classification of 938 mice across 12 generations based on SOA sensitivity.

Main Results:

The taster allele (Soa^t) was successfully introgressed onto a demitaster background.
Observed taster-demitaster proportions in offspring were consistent with Mendelian expectations for a single gene.
The study confirmed the monogenic control of SOA sensitivity in the developed congenic line.

Conclusions:

The C3.SW-Soaa congenic strain provides a valuable tool for taste research.
This three-strain congenic series enables detailed mechanistic studies of taste perception.
The findings reinforce the genetic basis of bitter taste sensitivity in mammals.

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