Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cap binding complexes and cellular growth control

S Mader1, N Sonenberg

  • 1Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Biochimie
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antiestrogens: structure-activity relationships and use in breast cancer treatment.

Journal of molecular endocrinology·2016
Same author

Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice.

Molecular psychiatry·2016
Same author

Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein.

Journal of neurology, neurosurgery, and psychiatry·2014
Same author

The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2014
Same author

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.

Oncogene·2014
Same author

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

Oncogene·2014
Same journal

Differential cardiac microRNA expression in anoxic Trachemys scripta elegans turtles.

Biochimie·2026
Same journal

Renal failure-driven luminal ammonia production impairs gut barrier function in CKD.

Biochimie·2026
Same journal

Conditional Knockout of Indoleamine 2, 3-Dioxygenase-1 in Osteoprogenitor Cells in Mice Results in Sex-dependent Differences in Bone Mass.

Biochimie·2026
Same journal

Sedentariness disrupts, while exercise restores, thermogenic and metabolic plasticity in inguinal adipose tissue of mice.

Biochimie·2026
Same journal

Chrononutrition as a modulator of retinal metabolic resilience: A translational framework linking circadian biology to ocular disease.

Biochimie·2026
Same journal

Heterologous expression, purification, and biophysical characterisation of the cobalt-dependent nitrile hydratase from Rhodococcus rhodochrous ATCC BAA-870.

Biochimie·2026
See all related articles

The eukaryotic initiation factor 4F (eIF-4F) complex regulates translation. New eIF-4E binding proteins (4E-BPs) control eIF-4F activity by sequestering eIF-4E, impacting cellular growth.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • The cap-binding complex eukaryotic initiation factor 4F (eIF-4F) is crucial for controlling translation initiation.
  • Overexpression of its limiting subunit, eukaryotic initiation factor 4E (eIF-4E), is linked to deregulated cellular growth.

Purpose of the Study:

  • To investigate the regulatory role of newly identified eIF-4E binding proteins (4E-BPs).
  • To elucidate the mechanism by which 4E-BPs modulate eIF-4E activity.

Main Methods:

  • Cloning of eIF-4E binding proteins (4E-BPs).
  • Analysis of protein-protein interactions and complex formation.

Main Results:

  • Discovery of 4E-BPs as regulators of eIF-4E activity.

Related Experiment Videos

  • Demonstration that 4E-BPs sequester eIF-4E, forming inhibitory complexes.

    • Conclusions:

    • A novel regulatory pathway for translation initiation involving 4E-BPs has been uncovered.
    • This pathway provides a new mechanism for controlling cellular growth through eIF-4E regulation.