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An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis
M J Starmans-Kool1, M M Fickers, M A Pannebakker
1Department of Internal Medicine, De Wever Hospital, Heerlen, The Netherlands.
Abstract:
A patient with idiopathic myelofibrosis is reported who developed a drug fever after treatment with hydroxyurea, a generally effective and well-tolerated drug in chronic myeloproliferative syndromes. Typically, this form of fever develops after a few weeks of exposure to the drug and disappears with discontinuation of the drug. Possible interactions with prostaglandin or leukotriene metabolism may play a role.
Insights
A patient developed drug fever from hydroxyurea treatment for idiopathic myelofibrosis. Fever resolved upon drug discontinuation, suggesting a potential role for prostaglandin or leukotriene metabolism.
Area of Science:
- Hematology
- Pharmacology
Background:
- Idiopathic myelofibrosis is a chronic myeloproliferative syndrome.
- Hydroxyurea is a common treatment for myeloproliferative disorders.
Observation:
- A patient with idiopathic myelofibrosis was treated with hydroxyurea.
- The patient developed a drug fever after several weeks of hydroxyurea therapy.
Findings:
- Drug fever is a known adverse effect of hydroxyurea.
- Fever resolved after discontinuing hydroxyurea treatment.
- The mechanism may involve prostaglandin or leukotriene metabolism.
Implications:
- Hydroxyurea, while effective, can cause drug fever.
- Monitoring for fever is important during hydroxyurea treatment.
- Further research into the mechanism of drug fever is warranted.