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BCR/ABL signal transduction
1Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202-5121, USA.
International Journal of Hematology
|April 1, 1995
Abstract:
A strong association between the Philadelphia chromosome (Ph1) and chronic myelogenous leukemia (CML) suggests that the Ph1 translocation plays a significant role in pathogenesis of CML. For this reason, Ph1-positive leukemias have been well studied from the molecular, clinical and cell biological perspective. In this review article, intracellular signalling events involving BCR/ABL fusion gene products are discussed in the context of the role of the Ph1 chromosome in human leukemia.