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Related Experiment Videos

Relaxin secretion in early pregnancy

J Quagliarello, B G Steinetz, G Weiss

    Obstetrics and Gynecology
    |January 1, 1979
    PubMed
    Summary

    Relaxin, a hormone from the corpus luteum, is detectable in early pregnancy. Its detection in blood may serve as a pregnancy test and indicate its role in maintaining early pregnancy.

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    Area of Science:

    • Reproductive Endocrinology
    • Hormone Biology

    Background:

    • Relaxin is a peptide hormone exclusively produced by the corpus luteum in pregnant women.
    • Human pregnancy corpora lutea extracts exhibit relaxin activity in bioassays.
    • This activity is quantifiable using a heterologous porcine radioimmunoassay (RIA).

    Purpose of the Study:

    • To investigate the presence and detectability of immunoreactive relaxin in human blood during early pregnancy.
    • To evaluate the potential of relaxin detection as an early pregnancy test.
    • To explore relaxin's role as a luteal factor in early pregnancy maintenance.

    Main Methods:

    • Utilized a heterologous porcine radioimmunoassay (RIA) to measure immunoreactive relaxin.
    • Analyzed blood samples from nonpregnant women and women in conception cycles.
    • Correlated relaxin immunoactivity levels with the timing of missed menses.

    Main Results:

    • Immunoreactive relaxin was undetectable in 51 nonpregnant women via RIA.
    • Relaxin immunoactivity became detectable in peripheral blood during conception cycles by the time of missed menses.
    • Elevated relaxin levels were observed in early pregnancy.

    Conclusions:

    • Relaxin detection in peripheral blood can serve as a potential pregnancy test.
    • Relaxin may function as a crucial luteal factor, alongside progesterone, for sustaining early pregnancy.
    • Further research into relaxin's specific mechanisms in pregnancy maintenance is warranted.

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