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Delayed systemic allergic reactions to corticosteroids

S E Whitmore1

  • 1Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Contact Dermatitis
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

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Delayed systemic corticosteroid reactions are rare but varied, presenting as skin eruptions. Patch and intradermal tests are key diagnostic tools for these infrequent adverse events.

Area of Science:

  • Dermatology
  • Allergy and Immunology

Background:

  • Corticosteroids are widely used systemically, intralesionally, and intra-articularly.
  • Delayed adverse reactions to corticosteroids are considered rare in clinical practice.

Purpose of the Study:

  • To review and summarize reported cases of generalized delayed systemic corticosteroid reactions.
  • To analyze patient presentation, evaluation methods, and diagnostic conclusions for these reactions.

Main Methods:

  • Literature review of reported cases of generalized delayed systemic corticosteroid reactions.
  • Tabulation of patient presentation, timing, cutaneous manifestations, and diagnostic evaluations.

Main Results:

  • Twenty-four cases of generalized delayed systemic corticosteroid reactions were identified in the literature.

Related Experiment Videos

  • Clinical presentations varied, including eczematous or exanthematous eruptions, with or without bullae or purpura.
  • Diagnosis was supported by positive patch or intradermal testing in 16 cases.

    • Conclusions:

    • Generalized delayed systemic reactions to corticosteroids are infrequently reported and exhibit considerable variability.
    • Patch and intradermal testing with standardized allergens are valuable for supporting the clinical diagnosis.
    • Further research may be needed to fully understand the incidence and mechanisms of these reactions.