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Roth spots seen on ophthalmoscopy: diseases with which they may be associated
1Connecticut Retina Consultants, P.C.
Connecticut Medicine
|May 1, 1995
Summary
Roth spots, white-centered hemorrhages, are not exclusive to subacute bacterial endocarditis (SBE). While classically linked to SBE, these ocular findings can indicate other systemic diseases, challenging their pathognomonic status.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Cardiology
Background:
- Roth spots are white-centered hemorrhages observed during fundoscopic examination.
- Historically, they were considered pathognomonic for subacute bacterial endocarditis (SBE).
Purpose of the Study:
- To review the pathogenesis of white-centered hemorrhages (Roth spots).
- To identify diseases other than SBE where Roth spots may occur.
Main Methods:
- Literature review on the pathogenesis and clinical significance of Roth spots.
- Analysis of case reports and studies documenting Roth spots in various conditions.
Main Results:
- Roth spots are not specific to SBE.
- Evidence suggests Roth spots can be associated with a range of other medical conditions.
Conclusions:
- The diagnostic utility of Roth spots is broader than previously assumed.
- Physicians should consider differential diagnoses beyond SBE when encountering Roth spots.