[The impact of diltiazem on aminophylline serum concentration--a clinical study]

Aminophylline was used in 64 hospitalized patients with asthma and the change of aminophylline serum concentration and clinical manifestations were observed before and after the addition of diltiazem. The results suggested that mean aminophylline serum concentration increased 0.2 percent (P > 0.05), FEV1 increased 9.2 percent (P < 0.01), PO2 increased 5.3 percent (P < 0.01), PCO2 decreased 7.1 percent (P < 0.01), after the addition of diltiazem. These data indicated that the addition of diltiazem did not change aminophylline serum concentration but ameliorate clinical manifestations. However, after the addition of diltiazem, due attention should be paid to the change of blood pressure.