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Solid-phase synthesis of oxytocin using iodotrichlorosilane as Boc deprotecting agent
K M Sivanandaiah1, V V Sureshbabu, S C Shankaramma
1Department of Studies in Chemistry, Central College, Bangalore University, Karnataka, India.
International Journal of Peptide and Protein Research
|April 1, 1995
Abstract:
Deprotection of the tert-butoxycarbonyl group during solid-phase synthesis of peptides can be conveniently and efficiently carried out using a neutral reagent, silicon tetrachloride/sodium iodide (iodotrichlorosilane). This simple and rapid method has been advantageously employed during the solid-phase synthesis of the pituitary hormone, oxytocin.