Unraveling the causes of hypertension and hypokalemia

Coexistence of the two conditions may be coincidental, so the first step is to rule out nonrenal causes. Overall, the two most common causes are diuretic therapy and primary aldosteronism. New clinical insights regarding three other conditions--glucocorticoid-remediable aldosteronism, apparent mineralocorticoid excess, and deoxycorticosterone hypersecretion syndrome--are also discussed.