Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic immunodeficiencies: cutaneous manifestations and recent progress

J L Arbiser1

  • 1Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA.

Journal of the American Academy of Dermatology
|July 1, 1995
PubMed
Summary

Genetic immunodeficiency disorders are increasingly recognized by dermatologists due to advances in diagnosis and therapy. Understanding these genetic conditions offers insights into common skin issues like eczema and infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Promoting intolerance: learning from warts.

The British journal of dermatology·2017
Same author

Comprehensive profiling of H-Ras signalling in angiosarcoma endothelium.

Clinical and experimental dermatology·2017
Same author

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.

Oncogene·2017
Same author

Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation.

Oncogene·2015
Same author

A tale of two macrophages: to Shb or not to Shb.

Acta physiologica (Oxford, England)·2015
Same author

Suppression of NF-κB activation by gentian violet promotes osteoblastogenesis and suppresses osteoclastogenesis.

Current molecular medicine·2014

Area of Science:

  • Immunology
  • Genetics
  • Dermatology

Background:

  • Genetic immunodeficiency disorders present significant dermatologic manifestations.
  • Advances in diagnosis and therapy are improving patient longevity.
  • Dermatologists are increasingly likely to encounter these complex cases.

Purpose of the Study:

  • To review the diagnosis, dermatologic manifestations, and therapy of genetic immunodeficiency disorders.
  • To highlight the relevance of understanding these disorders for common dermatologic conditions.

Main Methods:

  • Review of recent literature on genetic immunodeficiency disorders.
  • Discussion of cloned genes and their pathophysiology.
  • Analysis of clinical presentations and treatment strategies.

Related Experiment Videos

Main Results:

  • Significant progress in understanding the pathophysiology of genetic immunodeficiencies.
  • Identification and cloning of key genes (e.g., chronic granulomatous disease, X-linked immunodeficiencies, myeloperoxidase deficiency).
  • Dermatologic manifestations are a key feature requiring clinical attention.

Conclusions:

  • Understanding genetic immunodeficiencies aids in diagnosing and managing rare disorders.
  • Insights from these rare diseases can inform the understanding of common dermatologic conditions like eczema and cutaneous infections.
  • Multidisciplinary approaches are crucial for optimal patient care.