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Aminosidine sulphate in experimental giardiasis
H N Awadalla1, S H el-Gowhary, H A Sadaka
1Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
Journal of the Egyptian Society of Parasitology
|April 1, 1995
Summary
Aminosidine-sulphate effectively treated experimental giardiasis in rats, particularly under hyperacidity conditions. Drug efficacy was reduced in hypoacidity, highlighting the role of gastric acidity in treatment success.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Giardiasis, caused by Giardia lamblia, presents varied symptoms, including diarrhea and malabsorption.
- Current treatments for giardiasis often involve systemically absorbed drugs with potential side effects.
- Gastric acidity is a significant local factor influencing Giardia lamblia pathogenicity.
Purpose of the Study:
- To evaluate the efficacy of locally acting aminosidine-sulphate (gabbroral) in treating experimental giardiasis in rats.
- To investigate the impact of varying gastric acidity levels on the drug's therapeutic effect.
Main Methods:
- Experimental giardiasis was induced in a rat model.
- Gastric acidity was manipulated using indomethacin (indocid) for hyperacidity and cimetidine (cimetex) for hypoacidity.
- Aminosidine-sulphate was administered to assess treatment outcomes under different acidity conditions.
Main Results:
- Significant improvement in pathological findings and reduced parasitic counts were observed in rats with hyperacidity.
- Partial parasite eradication was noted in rats with normal gastric acidity.
- Aminosidine-sulphate showed no beneficial effect in rats with hypoacidity, as parasites invaded deeper intestinal layers.
Conclusions:
- Aminosidine-sulphate demonstrates potential as a locally acting agent for giardiasis treatment.
- Hyperacidity enhances the efficacy of aminosidine-sulphate by improving its local action against Giardia lamblia.
- Hypoacidity compromises the effectiveness of aminosidine-sulphate, suggesting careful consideration of gastric environment in treatment strategies.