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Aortic thrombosis in a dog with glomerulonephritis
1Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Science, Medical University of Southern Africa, Medunsa.
Journal of the South African Veterinary Association
|December 1, 1994
Summary
A Bearded Collie experienced leg pain and weakness due to a large aortic thrombus. This condition, linked to glomerulonephritis, caused significant protein loss and kidney issues.
Area of Science:
- Veterinary Medicine
- Cardiovascular Pathology
- Nephrology
Background:
- Bearded Collies can present with complex clinical signs including weakness and hind limb pain.
- Bilateral absence of femoral pulses suggests significant vascular compromise.
- Initial diagnostics revealed proteinuria, hypoproteinemia, hyperlipidemia, and azotemia, indicating systemic disease.
Observation:
- Quantitative proteinuria revealed a daily loss of 483 mg/kg.
- Non-selective angiography and ultrasonography identified a large caudal aortic thrombosis.
- Autopsy confirmed extensive aortic thrombus extending into iliac and femoral arteries, and a pulmonary artery thrombus.
Findings:
- Histopathology revealed subacute to chronic membranoproliferative glomerulonephritis in the kidneys.
- The aortic thrombus was the likely cause of the femoral pulse deficit and associated clinical signs.
- Coexisting pulmonary artery thrombus suggests a broader thrombotic event.
Implications:
- This case highlights the importance of investigating vascular abnormalities in dogs presenting with non-specific signs.
- Glomerulonephritis may predispose to or be associated with significant thromboembolic events.
- Understanding these associations can improve diagnostic and therapeutic strategies for canine cardiovascular and renal diseases.