Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Creatine kinase (CK)]

S Shoji1

  • 1Department of Neurology, Institute of Clinical Medicine, University of Tsukuba.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Creatine kinase (CK) is vital for muscle energy, with key isoenzymes like CK-MM, CK-MB, and CK-BB. This review details their roles, distribution, and clinical relevance in various tissues and conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fabrication of Hydrogen Boride Thin Film by Ion Exchange in MgB<sub>2</sub>.

Molecules (Basel, Switzerland)·2021
Same author

Laparoendoscopic Single-site Plus 1-port Donor Nephrectomy: Division of Roles to Shorten Warm Ischemic Time.

Transplantation proceedings·2018
Same author

Dissociated Agonist of Glucocorticoid Receptor or Prednisone for Active Rheumatoid Arthritis: Effects on P1NP and Osteocalcin Pharmacodynamics.

CPT: pharmacometrics & systems pharmacology·2017
Same author

Simple microfluidic formation of highly heterogeneous microfibers using a combination of sheath units.

Lab on a chip·2017
Same author

Anomalous connection of the left posterior renal vein with the left ascending lumbar vein in a Japanese cadaver.

Folia morphologica·2015
Same author

Increased undercarboxylated osteocalcin/intact osteocalcin ratio in patients undergoing hemodialysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014

Area of Science:

  • Biochemistry and enzymology
  • Cellular energy metabolism
  • Muscle physiology

Context:

  • Creatine kinase (CK) is crucial for cellular energy homeostasis, particularly in high-energy-demand tissues like skeletal muscle.
  • CK plays a significant role in the creatine kinase/phosphocreatine system, supporting ATP regeneration during muscle contraction and relaxation.
  • The enzyme's activity is closely linked to mitochondrial oxidative phosphorylation, highlighting its importance in cellular energy production.

Purpose:

  • To provide a comprehensive overview of creatine kinase (CK) and its isoenzymes.
  • To elucidate the distribution and function of CK isoenzymes in various tissues.
  • To discuss the clinical significance of CK isoenzymes in different physiological and pathological states.

Summary:

Related Experiment Videos

  • Creatine kinase (CK) is a key enzyme in energy metabolism, essential for muscle contraction and relaxation, and linked to mitochondrial oxidative phosphorylation.
  • The enzyme has multiple isoenzymes, including CK-MM, CK-MB, CK-BB, and a mitochondrial form (CKm), each with distinct tissue distributions and electrophoretic properties.
  • The abstract also covers serum CK isoenzymes (primarily CK-MB and CK-BB) and their association with conditions affecting the myocardium, skeletal muscle, central nervous system, and other organ systems, as well as specific physiological states like pregnancy and labor.

Impact:

  • Understanding creatine kinase isoenzymes is critical for diagnosing and managing muscle disorders and other conditions.
  • This compendium serves as a valuable resource for researchers and clinicians investigating creatine kinase's role in health and disease.
  • Further research into CK isoenzymes may reveal novel therapeutic targets for metabolic and neuromuscular diseases.