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Related Experiment Videos

[Gamma-enolase (gamma-eno)]

R Koyama1

  • 1Hokkaido Prefecture Sapporo Kitano Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 1, 1995
PubMed
Summary

Serum gamma-enolase is a valuable tumor marker for amine precursor uptake and decarboxylation (APUD) cell-derived cancers. Elevated levels in cerebrospinal fluid also indicate neurological disorders, highlighting gamma-enolase

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Area of Science:

  • Biochemistry
  • Oncology
  • Neurology

Context:

  • Enolase isozymes, dimers of alpha, beta, and gamma subunits, play a role in glycolysis.
  • Gamma-enolase is found in serum and cerebrospinal fluid.
  • APUD cell tumors include neuroblastoma, small cell lung carcinoma, and carcinomas of the thyroid, pancreas, and gut.

Purpose:

  • To review studies on gamma-enolase's role as a tumor marker and in neurological disorders.
  • To highlight the diagnostic utility of serum and cerebrospinal fluid gamma-enolase levels.

Summary:

  • Enolase catalyzes a key step in glycolysis.
  • Serum gamma-enolase is a significant tumor marker for APUD cell-derived neoplasms.
  • Elevated cerebrospinal fluid gamma-enolase levels are associated with various neurological conditions.

Impact:

  • Determining serum gamma-enolase levels aids in diagnosing specific cancers.
  • Cerebrospinal fluid gamma-enolase measurements can assist in diagnosing neurological disorders.
  • This review consolidates current research on gamma-enolase's clinical applications.

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