Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunosuppression in Nigerians with hookworm infection

B O Olatunde1, G C Onyemelukwe

  • 1Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

African Journal of Medicine and Medical Sciences
|September 1, 1994
PubMed
Summary

Hookworm infection in humans, caused by Necator americanus and Ancylostoma duodenale, leads to reduced T-lymphocyte levels and impaired immune responses. This study indicates significant immunosuppression in patients with hookworm infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Obesity on Resistin Concentrations in Normal, Pre-Obese and Obese Apparently Healthy Nigerian-Africans.

West African journal of medicine·2022
Same author

RAST-specific IgE to egg and milk in Nigerian asthmatic patients.

African journal of medicine and medical sciences·2011
Same author

Fleroxacin vs Ciprofloxacin in the Management of Typhoid Fever: A Randomised, Open, Comparative Study in Nigerian Patients.

Clinical drug investigation·2008
Same author

Plasma insulin response to oral glucose tolerance test in type-2 Nigerian diabetics.

East African medical journal·2005
Same author

T-lymphocyte subsets in patients with hookworm infection in Zaria, Nigeria.

African journal of medicine and medical sciences·2003
Same author

Snake bite in Nigeria.

African journal of medicine and medical sciences·2003

Area of Science:

  • Immunology
  • Infectious Diseases
  • Tropical Medicine

Background:

  • Hookworm infection is a prevalent global health issue.
  • The impact of hookworm infection on the human immune system requires further elucidation.

Purpose of the Study:

  • To investigate the immune status of patients with hookworm infection.
  • To assess T-lymphocyte levels and leukocyte migration in hookworm-infected individuals.

Main Methods:

  • Comparison of sheep erythrocyte rosette-forming T-lymphocytes (SE-TL) and leukocyte migration responses.
  • Patients were grouped based on anemia severity (marked, moderate, none).
  • Inclusion of healthy controls without parasitic infections.

Main Results:

Related Experiment Videos

  • Markedly reduced SE-TL levels in hookworm-infected patients compared to healthy controls (P < 0.001).
  • Significantly impaired leukocyte migratory responses to purified protein derivative (P.P.D) in all patient groups (P < 0.05).
  • No significant difference in SE-TL levels among patient groups with varying anemia severity.

Conclusions:

  • Results support the hypothesis of immunosuppression in hookworm infection.
  • Hookworm infection negatively impacts cellular immune functions.
  • Further research is warranted to understand the mechanisms of immunosuppression in hookworm disease.