Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A practical guide to intensive insulin therapy

P J Campbell1, M E May

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

The American Journal of the Medical Sciences
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune status and the efficacy of adjuvant radiotherapy for patients with localized Merkel cell carcinoma of the head and neck.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2020
Same author

Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.

Leukemia·2017
Same author

Erratum to: Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.).

Lipids·2017
Same author

COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.

Current protocols in human genetics·2016
Same author

Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.).

Lipids·2016
Same author

A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma.

Blood cancer journal·2016
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of acute myeloid leukemia patients admitted to the intensive care unit within 100 days of allogeneic hematopoietic stem cell transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Intensive insulin therapy (IIT) significantly reduces microvascular complications in diabetes. This guide helps primary care physicians manage IIT, emphasizing benefits and risks like severe hypoglycemia.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Clinical Medicine

Background:

  • The Diabetes Control and Complications Trial (DCCT) demonstrated the efficacy of intensive insulin therapy (IIT) in reducing microvascular complications.
  • Microvascular complications include retinopathy, nephropathy, and neuropathy in insulin-dependent diabetes mellitus.
  • Most diabetes patients are managed by primary care physicians, not endocrinologists, necessitating practical IIT guidance for this group.

Purpose of the Study:

  • To provide primary care physicians with practical guidance on initiating and managing intensive insulin therapy (IIT).
  • To define suitable candidates for IIT and outline its benefits for patients with diabetes.
  • To highlight potential complications of IIT, particularly severe hypoglycemia.

Main Methods:

Related Experiment Videos

  • The article reviews the findings of the Diabetes Control and Complications Trial (DCCT).
  • It outlines practical strategies for the initiation and ongoing management of IIT.
  • It discusses patient selection criteria for IIT and emphasizes risk mitigation.

Main Results:

  • Intensive insulin therapy (IIT) was proven effective in reducing the incidence and severity of microvascular complications.
  • Improvements were observed in retinopathy, nephropathy, and neuropathy among patients receiving IIT.
  • Severe hypoglycemia was identified as a major risk requiring careful management.

Conclusions:

  • Intensive insulin therapy (IIT) offers significant benefits in managing microvascular complications of diabetes.
  • Primary care physicians can effectively manage IIT with appropriate knowledge and patient selection.
  • Vigilance regarding severe hypoglycemia is crucial for the safe and successful implementation of IIT.