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Related Experiment Videos

Fermentations by saccharolytic intestinal bacteria

T L Miller, M J Wolin

    The American Journal of Clinical Nutrition
    |January 1, 1979
    PubMed
    Summary
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    Intestinal anaerobes ferment carbohydrates via the Embden-Meyerhof-Parnas pathway, producing key intermediates like pyruvate. Human gut fermentation pathways, involving volatile acids, resemble those found in rumen fermentation.

    Area of Science:

    • Microbiology
    • Biochemistry
    • Gastroenterology

    Background:

    • Intestinal tract harbors numerous nonsporing anaerobic bacteria.
    • Carbohydrate fermentation is a primary metabolic process in the gut microbiome.

    Purpose of the Study:

    • To elucidate the fermentation pathways of intestinal anaerobes.
    • To compare human gut fermentation with rumen fermentation.

    Main Methods:

    • Analysis of carbohydrate fermentation pathways (Embden-Meyerhof-Parnas scheme).
    • Identification of key fermentation intermediates and end products.
    • Derivation of fermentation equations from volatile acid concentrations in human feces.

    Main Results:

    • Pyruvate is a central intermediate, oxidized to acetyl coenzyme A.

    Related Experiment Videos

  • Hydrogen (H2) is produced from low-potential electron acceptors or NADH.
  • End products include lactate, succinate, propionate, ethanol, acetate, butyrate, and formate.
  • Heme and vitamin B12 influence succinate and propionate formation in human Bacteroides.

    • Conclusions:

    • Human intestinal fermentation pathways are largely conserved among nonsporing anaerobes.
    • The overall fermentation in the human large intestine mirrors rumen fermentation based on volatile acid profiles.