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Disseminated intravascular coagulation in the newborn
American Journal of Diseases of Children (1960)
|January 1, 1979
Summary
Disseminated intravascular coagulation (DIC) in newborns is linked to maternal issues, low Apgar scores, hyaline membrane disease, and sepsis. Treatment regimens did not affect mortality, but older gestational age and higher birth weights improved survival.
Area of Science:
- Neonatal Medicine
- Hematology
- Pathology
Background:
- Disseminated intravascular coagulation (DIC) is a serious condition in newborns.
- Identifying predisposing factors and diagnostic criteria is crucial for neonatal care.
Purpose of the Study:
- To review cases of neonatal DIC and identify predisposing factors.
- To establish common diagnostic criteria for autopsy-confirmed DIC in newborns.
- To evaluate the impact of therapeutic regimens on mortality and survival.
Main Methods:
- Retrospective review of 53 neonatal disseminated intravascular coagulation (DIC) cases.
- Inclusion of 29 cases with autopsy confirmation.
- Analysis of predisposing factors, diagnostic markers, and treatment outcomes.
Main Results:
- Common predisposing factors included maternal complications (60%), hyaline membrane disease (62%), low Apgar scores (30%), and sepsis (26%).
- Diagnostic criteria included fibrin degradation products, low factor V activity, prolonged prothrombin time, prolonged partial thromboplastin time, and/or thrombocytopenia.
- No significant difference in coagulation response or mortality was observed across different therapeutic regimens.
Conclusions:
- Neonatal DIC is associated with specific maternal and neonatal complications.
- Established laboratory findings aid in diagnosing DIC in newborns.
- Survival appears linked to gestational age, birth weight, and Apgar scores, independent of treatment variations.