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A general model for the evolution of recombination

N H Barton1

  • 1Division of Biological Sciences, University of Edinburgh, UK.

Genetical Research
|April 1, 1995
PubMed
Summary

Recombination can be favored by selection if it helps overcome negative epistasis between favorable alleles, facilitating adaptation. This study provides a general framework linking selection on recombination to fitness variation, offering testable predictions.

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Area of Science:

  • Evolutionary genetics
  • Population genetics

Background:

  • Multilocus selection models typically assume constant recombination rates.
  • Understanding how recombination rates evolve under selection is crucial for evolutionary dynamics.

Purpose of the Study:

  • To extend multilocus selection models to include genotype-dependent recombination.
  • To investigate the conditions under which recombination rate modifiers are selected.
  • To establish a general relationship between selection on recombination and fitness variation.

Main Methods:

  • Developed a general representation of multilocus selection allowing genotype-dependent recombination.
  • Analyzed the evolution of recombination modifiers with small effects.
  • Derived explicit formulas for selection on modifiers under weak epistasis.
  • Checked approximations against exact calculations and existing literature.

Main Results:

  • Recombination can be favored by facilitating adaptation to directional selection, particularly with weak negative epistasis.
  • Selection on recombination modifiers is linked to additive and non-additive variances in fitness.
  • Fluctuating epistasis is unlikely to favor increased recombination.

Conclusions:

  • The evolution of recombination is primarily driven by its role in facilitating adaptation under directional selection.
  • The study provides a theoretical framework for experimentally testing the relationship between selection on recombination and fitness variation.

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