Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Vaccinations

Vaccinations

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

Methods Of Healthcare Delivery System

Methods Of Healthcare Delivery System

At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...

Active versus Passive Immunity

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnostic accuracy of TB-LAMP and smear microscopy for pulmonary TB in active case finding.

IJTLD open·2026

Same author

Enhancing tuberculosis patient detection and care through community volunteers in the urban poor, The Philippines.

Public health action·2018

Same author

Tuberculosis Diagnostic Committees' contribution to the National TB Program in Manila and Quezon Cities.

Public health action·2015

Same author

Effects of infant mortality, family planning and socioeconomic factors on fertility reduction in developing countries.

Environmental health and preventive medicine·2011

Same author

Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries.

The Japanese journal of physiology·2001

Same author

K(ATP) channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo.

European journal of pharmacology·2001

Search research articles

Related Experiment Video

Updated: Dec 24, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

Immunization coverage and infant mortality rate in developing countries

A Shimouchi¹, K Ozasa, K Hayashi

¹Kyoto Prefectural University of Medicine, Department of Preventive Medicine, Japan.

Asia-Pacific Journal of Public Health

|January 1, 1994

Summary

This summary is machine-generated.

Immunization coverage (IMC) is a key predictor of infant mortality rate (IMR) in developing nations. Higher IMC correlates with lower IMR, indicating its role in primary healthcare availability.

Keywords:

Child Health Services Child Survival Correlation Studies Data Analysis Death Rate--determinants Delivery Of Health Care Demographic Factors Developing Countries Health Health Services Immunization--beneficial effects Infant Mortality--determinants Intermediate Variables Length Of Life Maternal-child Health Services Mortality Mortality Determinants Multivariate Analysis Population Population Dynamics Primary Health Care Research Methodology Statistical Studies Studies Survivorship

More Related Videos

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

Related Experiment Videos

Last Updated: Dec 24, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

Area of Science:

Global Health
Public Health Policy
Demography

Background:

Infant mortality rate (IMR) remains a critical global health challenge, particularly in developing countries.
Assessing primary healthcare (PHC) service availability is crucial for understanding IMR determinants.
Immunization coverage (IMC) is proposed as a potential proxy indicator for PHC services.

Purpose of the Study:

To investigate if immunization coverage (IMC) predicts infant mortality rate (IMR) in developing countries.
To determine if IMC serves as a proxy for primary healthcare (PHC) service availability.
To analyze the relationship between IMR and other socioeconomic and healthcare indicators.

Main Methods:

Multiple regression analysis was employed to assess the relationship between IMR and selected variables.
Data were analyzed for 97 developing countries, representing over 97% of the global developing population.
Simple correlation analysis examined IMC's association with specific PHC indicators.

Main Results:

IMR was significantly correlated with IMC, per capita GNP, total fertility rate, and adult literacy rate (p < 0.001).
These four variables explained over 80% of the variation in IMR across 97 developing countries (R=0.921).
IMC showed strong correlations with primary healthcare access, maternal care, delivery care, and infant care indicators (p < 0.001).

Conclusions:

Immunization coverage is a significant predictor of infant mortality rate.
IMC can serve as a valuable proxy indicator for the availability of primary healthcare services in developing countries.
Improving immunization coverage is a critical health intervention for reducing infant mortality.