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Related Experiment Videos

Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse

R Pernas-Alonso1, A E Schaffner, C T Hansen

  • 1International Institute of Genetics and Biophysics, CNR, Naples, Italy.

Neuroreport
|March 7, 1995
PubMed
Summary
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Reduced acetylcholinesterase gene expression is an early molecular marker in wobbler mice, preceding motoneurone degeneration. This finding aids in identifying the wobbler mutation before disease onset.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Homozygote wobbler mice exhibit motoneurone degeneration.
  • Gene expression of choline acetyltransferase, trkC receptor, and F3 adhesion molecule is comparable between wobbler and wild-type mice during development.

Purpose of the Study:

  • To investigate early molecular markers for the wobbler mutation.
  • To determine if acetylcholinesterase gene expression changes precede motoneurone degeneration in wobbler mice.

Main Methods:

  • Analysis of gene expression in wobbler and wild-type mice at different postnatal ages (P5, P10, P21).
  • Quantification of acetylcholinesterase mRNA levels using molecular techniques.

Main Results:

Related Experiment Videos

  • Acetylcholinesterase mRNA levels were reduced by approximately 50% in P5 and P10 wobbler mice (putative homozygotes).
  • At P21, homozygous wobbler mice showed highly reduced expression, while heterozygotes exhibited a 35% reduction compared to normal values.
  • Reduced acetylcholinesterase gene expression was observed before the onset of clinical symptoms.

    • Conclusions:

    • Reduced acetylcholinesterase gene expression serves as an early molecular marker for the wobbler mutation.
    • This finding is similar to medium neurofilament gene over-expression, indicating potential shared or parallel molecular pathways.