Related Experiment Videos
Pruritus associated with intravenous rifampin
1Pharmacy Corporation of America, Kennewick, WA 99336, USA.
The Annals of Pharmacotherapy
|March 1, 1995
Summary
Intravenous rifampin likely caused moderate pruritus in a patient receiving treatment for methicillin-resistant Staphylococcus epidermidis. This adverse reaction resolved after discontinuing the antibiotic, highlighting a potential side effect for clinicians.
Area of Science:
- Pharmacology
- Clinical Medicine
- Adverse Drug Reactions
Background:
- A patient with methicillin-resistant Staphylococcus epidermidis (MRSA) received vancomycin and subsequently intravenous rifampin.
- The patient had a complex medical history including uterine carcinoma, radiation-induced enteritis, congestive heart failure, and renal insufficiency.
Observation:
- Pruritus developed three days after initiating intravenous rifampin therapy.
- The pruritus began 30 minutes after the infusion and lasted 6-8 hours.
- Symptoms resolved upon discontinuation of rifampin.
Findings:
- This case suggests a probable link between intravenous rifampin and moderate pruritus.
- The adverse event occurred despite the patient's other comorbidities and medications.
Implications:
- Clinicians should be aware of the potential for pruritus associated with intravenous rifampin.
- This highlights a possible adverse effect for both intravenous and oral rifampin formulations.