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Exercise increases systemic nitric oxide production in men

S M Bode-Böger1, R H Böger, E P Schröder

  • 1Institute of Clinical Pharmacology, Hanover Medical School, Germany.

Journal of Cardiovascular Risk
|August 1, 1994
PubMed
Summary
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Exercise increases nitric oxide (NO) formation, indicated by higher urinary nitrate and cyclic GMP excretion in both trained and untrained men. This NO production may aid vasodilation and explain exercise benefits for vascular health.

Area of Science:

  • Exercise Physiology
  • Cardiovascular Health
  • Biochemistry

Background:

  • Systemic nitric oxide (NO) formation plays a crucial role in vascular function.
  • Understanding exercise's impact on NO pathways is vital for cardiovascular health.
  • Endurance training may influence NO production during physical activity.

Purpose of the Study:

  • To compare the effects of acute exercise on systemic nitric oxide (NO) formation in endurance-trained versus untrained men.
  • To assess NO formation by measuring urinary excretion of nitrate and cyclic guanosine monophosphate (cGMP).

Main Methods:

  • Submaximal exercise test (30 min at 60% maximal work capacity) performed by 10 endurance-trained and 6 untrained men.
  • Hourly assessment of urinary nitrate excretion via gas chromatography.

Related Experiment Videos

  • Hourly assessment of urinary cyclic guanosine monophosphate (cGMP) excretion via radioimmunoassay.

    • Main Results:

    • Urinary nitrate excretion significantly increased (more than doubled) during exercise in both trained and untrained groups, returning to baseline post-exercise.
    • Resting urinary cyclic guanosine monophosphate (cGMP) was four times higher in endurance-trained men compared to untrained men.
    • Exercise approximately doubled cGMP excretion in both groups, with levels returning to baseline post-exercise. Urinary nitrate and cGMP excretion showed a significant correlation.

    Conclusions:

    • Acute submaximal exercise enhances nitric oxide (NO) formation, evidenced by increased urinary nitrate and cyclic guanosine monophosphate (cGMP) excretion.
    • This exercise-induced NO increase likely contributes to vasodilation during physical activity.
    • The findings suggest that enhanced NO production may partly explain the cardiovascular benefits of physical training, particularly in patients with vascular diseases.